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Recombinant expression systems as defined herein will express RNA, polypeptides or proteins endogenous to the cell upon induction of the regulatory elements linked to the endogenous DNA segment or gene to be expressed. Is hydrogen and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydroxy); 8-substituted doxycycline (eg, wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl, R 5 is hydroxyl and X is CR 6R 6′, wherein R 6 is methyl and R 6′ is hydrogen); or 8-substituted sancycline (wherein R 4 is NR 4′R 4″; R 4′ and R 4″ are methyl; R 5 is hydrogen and X is CR 6R 6″ wherein R 6 and R 6′ are hydrogen atoms! When changing to propranolol hydrochloride extended-release capsules from conventional propranolol, a possible need for retitration upwards should be considered, especially to maintain effectiveness at the end of the dosing interval!

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